In this discussion, Charlotte Pawlyn, BA, MBBChir, MRCP, PhD, FRCPath, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK, and Rakesh Popat, MD, PhD, University College London Hospitals NHS Foundation Trust, London, UK, comment on the identification and management of patients with newly diagnosed high-risk multiple myeloma, highlighting data from various UK clinical trials. Dr Pawlyn and Dr Popat then discuss the prognostic value of MRD, debating the different techniques and thresholds currently used in clinical practice. Finally, Dr Pawlyn and Dr Popat talk on the optimal management of frail patients with multiple myeloma and comment on the recent approval of teclistamab by the European Commission, questioning how to best deliver this agent. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA.
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