Guillermo José Ruiz-Argüelles, MD, FRCP, Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico, summarizes the results of a Latin American study evaluating high-dose melphalan prior to autologous hematopoietic stem cell transplantation (autoHSCT) in patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), highlighting the benefits of this preparative regimen. This strategy allows to deliver autoHSCT without freezing cells and is cheaper than other preparative regimens. Overall, the study demonstrated that high-dose melphalan was non-inferior to BEAM and mini-BEAM preparatory regimens. This interview took place at the Transplantation & Cellular Therapy (TCT) Meetings of ASTCT™ and CIBMTR® 2022 in Salt Lake City, Utah.