Niels van de Donk, MD, PhD, VU University Medical Center, Amsterdam, The Netherlands, discusses data from a current phase I/II clinical trial (NCT02773030) of a novel cereblon E3 ligase modulatory compound (CELMoD), iberdomide (CC-220), in relapsed/refractory multiple myeloma (R/R MM). Results show that iberdomide has notable clinical activity and favorable tolerability in heavily pretreated patients with R/R MM. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.