ASH 2023 | Replacing dexamethasone in transplant-ineligible multiple myeloma: the REST study
Fredrik Schjesvold, MD, PhD, Oslo University Hospital, Oslo, Norway, comments on the REST study (NCT04939844), which aims to investigate the replacement of the corticosteroid dexamethasone in therapeutic regimens utilized for the treatment of transplant-ineligible multiple myeloma (MM), to improve patient quality of life and decrease the risk of infection. In this study, patients are treated with a combination of isatuximab, bortezomib, and lenalidomide, along with minimal dexamethasone until disease progression, with preliminary findings of this treatment approach demonstrating encouraging efficacy and a tolerable safety profile. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Honoraria for lectures and educational material: Skylite DX, Schain, Novartis, Janssen-Cilag, Takeda, Pfizer, Oncopeptides, Amgen, Sanofi, Bristol Myers Squibb, Daiichi Sankyo, Celgene, GlaxoSmithKline, Abbvie
Consultancy: Janssen-Cilag, Takeda, Oncopeptides, Sanofi, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Abbvie
Research Funding: Janssen-Cilag, Oncopeptides, Sanofi, Targovax, Celgene, GlaxoSmithKline
