Frontline transplant-ineligible multiple myeloma (MM) is typically treated with VMP (bortezomib, melphalan, prednisolone) or Rd (lenalidomide, dexamethasone) based regimens. However, efforts have recently been made to combine these treatments, as discussed here by Kwee Yong, PhD, FRCP, FRCPath, from University College London, London, UK. Prof. Yong highlights the RVd (lenalidomide, bortezomib, dexamethasone) lite treatment protocol, as well as alternating or sequential regimens.