Gareth John Morgan, MD, FRCP, FRCPath, PhD, from the Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, talks to us about the issue of multiple myeloma (MM) patients relapsing relatively quickly when treated with targeted immunotherapy and explains that this may be due to the possibility that not all tumours carry the mutation that is being targeted. He also notes that venetoclax, an antibody that can specifically target the 11;14 subtype of MM, is particularly promising and he believes that the future of MM therapy will be focused on developing more targeted strategies. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.