Enrique Ocio, MD, PhD, Marqués de Valdecilla University Hospital, Santander, Spain, outlines current and emerging treatment strategies for patients with triple-class refractory multiple myeloma, which currently include belantamab mafodotin and selinexor. The recent introduction and development of CAR-T therapy and bispecific antibodies in this setting is changing the treatment landscape of patients with triple-class refractory disease. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.