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ASH 2025 | The potential of targeting mutant calreticulin with immunotherapy for the treatment of MPNs
Ciro Rinaldi, MD, PhD, Lincoln County Hospital, Lincoln, UK, discusses the potential of targeting mutant calreticulin with immunotherapy for the treatment of myeloproliferative neoplasms (MPNs). Prof. Rinaldi notes that while the data are still limited, the use of a monoclonal antibody to target a mutated protein in MPN is a novel concept, with promising results in terms of tolerability and response. This interview took place at the 67th ASH Annual Meeting and Exposition, held in Orlando, FL.
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Transcript
There are interesting data on Phase I/II, using antibodies against the mutant calreticulin, which are promising. It’s a different context, it’s a different concept. So it’s immunotherapy, which we haven’t had in MPN for quite a while. I think data are still limited, you know, this is more core to patients. I think we need to see in terms of long-term results. But it’s probably the first time that we use a monoclonal antibody to target a mutated protein in MPN...
There are interesting data on Phase I/II, using antibodies against the mutant calreticulin, which are promising. It’s a different context, it’s a different concept. So it’s immunotherapy, which we haven’t had in MPN for quite a while. I think data are still limited, you know, this is more core to patients. I think we need to see in terms of long-term results. But it’s probably the first time that we use a monoclonal antibody to target a mutated protein in MPN. I think I’m very excited to see what’s going to happen in the future. I think the data are promising in terms of tolerability and some results in terms of response, but I think there is a way to go.
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