Evangelina Papadavid, MD, PhD, of the National and Kapodistrian University of Athens, Greece, and Marios Koumourtzis, MD, of the University of Athens Medical School, Andreas Syggros Hospital, Athens, Greece, discuss unmet needs in cutaneous T-cell lymphoma (CTCL), highlighting challenges around diagnosis, the need to identify accurate prognostic factors and the need for curative therapies. This interview took place at the EORTC Cutaneous Lymphoma Group 20-21 meeting in Marseille.