Amir Fathi, MD, MPH, Massachusetts General Hospital Cancer Center, Boston, MA, summarizes the latest updates in the field of acute myeloid leukemia (AML), highlighting a new menin inhibitor and studies of novel combinations of IDH inhibitors and FLT3 inhibitors, such as with the BCL2 inhibitor venetoclax, as well as the future role of antibody-drug conjugates, bispecific antibodies and CAR T-cell therapy. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.