EBMT 2026 | The importance of multidisciplinary clinical intervention in the management of SOS and VOD

VOD/SOS is a topic that we discuss and address at every conference because it is a rare complication but due to its rarity it is very difficult to be familiar with it. Also the transplant platform changed over the last few years, therefore some features are different and also have different diagnostic criteria and a growing list of risk factors for these complications. Both nurses and doctors have the same aim when they are looking after transplant patients, offering a safe and effective procedure and a combined evaluation of a nurse and transplant physician can improve the differential diagnosis process and can offer a prompt diagnosis. In our experience in the previous institution where I worked, we analyzed our approach with a weekly ward round, and thanks to this tool, we were able to identify VOD and start treatment in moderate and severe cases without any delay. And very interesting, we became aware that late-onset VOD does exist. Indeed, in our manuscript, 32% of patients had late-onset VOD. This multidisciplinary approach had also some other effects not on patients but in the broad spectrum of the transplant team because other healthcare professionals became aware of these rare complications. Also, doctors in training became aware and familiar with these complications and this tool allowed us to make a better diagnosis, an earlier diagnosis but it has also an educational value for other healthcare professionals within the transplant field.

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