Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD, of the University College London Hospitals, London, UK, evaluates the use of personalized medicine in multiple myeloma. Specifically discussed is the importance of tumor profiling and subsequently treating patients based on molecular signatures identified, for example, aberrant BCL-2 and MCL-1 expression. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).