Saad Usmani, MD, FACP, Levine Cancer Institute, Charlotte, NC, discusses the INSIGHT MM study (NCT02761187), the largest prospective, observational study in multiple myeloma (MM) to date, following approximately 4,200 patients from 15 countries. Here he discusses the analysis of randomized controlled trials eligibility, with a focus on the treatment of frail MM patients in the real world. This interview was recorded at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.