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ASH 2023 | Selinexor-based triplet regimens in multiple myeloma

Gary Schiller, MD, University of California, Los Angeles, CA, discusses the possibility of using selinexor-based triplet regimens (for example, selinexor with dexamethasone and carfilzomib) for the treatment of heavily pretreated patients with multiple myeloma (MM) who have previously experienced treatment failure with anti-CD38 monoclonal antibodies. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

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Disclosures

Speakers Bureau: Stemline Therapeutics, Astellas Pharma, Sanofi, Kite, AbbVie, Jazz Pharmaceuticals, Incyte, Bristol Myers Squibb, Karyopharm Therapeutics; Research Funding: Geron, REGiMMUNE, Samus Therapeutics, Takeda, Mateon Therapeutics, Sangamo Bioscience, Deciphera, FORMA Therapeutics, Astellas Pharma, Sanofi, Sellas Life Sciences, Kite, Delta-Fly Pharma, Daiichi Sankyo, AbbVie, Precog, Jazz Pharmaceuticals, Celgene, Novartis, Incyte, Stemline Therapeutics, Trovagene, Bristol Myers Squibb, Amgen, Tolero Pharmaceuticals, Pfizer, Onconova Therapeutics, Actinium Pharmaceuticals, Karyopharm Therapeutics, Genentech/Roche, Gamida Cell, Fujifilm, Constellation Pharmaceuticals, Celator, Arog, Actuate Therapeutics, Agios, ElevateBio, Ono Pharmaceutical, AVM Biotechnology, Syros Pharmaceuticals, Kronos Bio; Consultancy: Astellas Pharma, AbbVie, Jazz Pharmaceuticals, Celgene, Novartis, Incyte, Agios, Ono Pharmaceutical; Current equity holder in publicly-traded company: Bristol Myers Squibb, Amgen, Johnson & Johnson.