Gary Schiller, MD, University of California, Los Angeles, Los Angeles, CA, outlines findings of a Phase I dose escalation study of the oral epichaperome inhibitor zelavespib in patients with relapsed myelofibrosis (MF; NCT03935555). Overall, the results demonstrated that zelavespib was well tolerated. Zelavespib has now been selected for a randomized Phase II trial which will investigate the therapeutic potential of the epichaperome inhibitor in combination with ruxolitinib in patients with relapsed MF. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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