Graham Jackson, MBBS, FRCP, FRCPath, MD, Newcastle upon Tyne Hospitals NHS Trust, Newcastle, UK, reports promising outcomes from the Myeloma XI study (NCT01554852), where newly diagnosed multiple myeloma patients were administered the quadruplet of carfilzomib, cyclophosphamide, lenalidomide and dexamethasone (KCRD). This interview took place at the Controversies in Multiple Myeloma (COMy) 2019 World Congress in Paris, France.