Francesco Maura, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, speaks on the use of genomic profiling to analyze temporal changes and predict prognosis in high-risk smoldering multiple myeloma (HR-SMM). In this study, whole-genome sequencing (WGS) was employed to reveal early genomic translocations in HR-SMM that were associated with poor treatment outcomes, with early gains of 1q being a strong predictor of a poor prognosis. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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