Nathan Sweeney, PhD, HealthTree, Lehi, UT, briefly discusses a study which investigated whether receiving high-dose melphalan would increase mutation burden and risk level in myeloma patients. Dr Sweeney discusses some results from this study and the impact of both high-dose melphalan and standard chemotherapy on disease burden. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.