Hermann Einsele, MD, FRCP, University of Würzburg, Würzburg, Germany, discusses the role of tandem autologous stem cell transplantation (ASCT) in multiple myeloma. Recently reported results from the Phase III EMN02/HO95 trial (NCT01208766) showed that tandem transplantation provided higher response rates and longer progression-free survival, compared to single transplantation, in patients with newly diagnosed myeloma. This improvement was most notable in patients with a high-risk cytogenetic profile. Prof. Einsele comments that most centers across Europe are now offering tandem transplantation to high-risk patients. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA.