Maria-Victoria Mateos, MD, PhD, from the University Hospital of Salamenca, Salamenca, Spain, talks to us about the importance of individualising treatment for elderly patients with multiple myeloma (MM), whose population is highly heterogenous due to variations in their degree of fitness and frailty. She describe that as the median age of diagnosis of MM is over 65 years, treatment for MM is most relevant in the elderly population. This interview was filmed at the American Society of Oncology (ASCO) 2017 Annual Meeting in Chicago, IL.