Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, shares some highlights from COMy 2022 and take-home messages. Dr Cerchione discusses many important points, including the need to use the best treatment options in the frontline setting, the benefit of combination approaches, the promise of novel immunotherapies, and the importance of genomic profiling of patients. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.