In this video, Peter Hillmen, MBChB, FRCP, FRCPath, PhD, University of Leeds, Leeds, UK, shares his insights into the use of selective next-generation Bruton’s tyrosine kinase (BTK) inhibitors, by presenting some early results from arm D of the SEQUOIA (BGB-3111-304; NCT03336333) trial. Dr Hillmen discusses the findings from this trial, including the high tolerability and good levels of minimal residual disease (MRD) eradication observed when using zanubrutinib in combination with venetoclax for del(17p) patients with chronic lymphocytic leukemia (CLL). This interview was filmed at the 63rd ASH Annual Meeting and Exposition Congress, Atlanta, GA, 2021.