Heinz Ludwig, MD, of the Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, and Hermann Einsele, MD, FRCP, of the University of Würzburg, Würzburg, Germany, outline the key sessions and topics discussed during the 18th International Myeloma Workshop (IMW) meeting. Prof. Ludwig talks on sessions covering the latest insights into the molecular mechanisms of myeloma, updated clinical trial data on the treatment of newly-diagnosed patients, as well as the importance of transplant. This interview took place during the IMW 2021 congress.