Graham Jackson, MBBS, FRCP, FRCPath, MD, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK, shares some insights into treatment options available for transplant-ineligible multiple myeloma patients. Prof. Jackson first highlights the importance of clearly defining transplant-eligible versus ineligible, and then discusses treatment options available for transplant-ineligible patients, including lenalidomide plus dexamethasone and ixazomib. Prof. Jackson then discusses some clinical trials which have shown that combination therapies are very promising for transplant-ineligible patients, including the MAIA trial (NCT02252172) and the ALCYONE trial (NCT02195479). This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.