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SOHO 2022 | Strategies to manipulate the immune system in myeloid malignancies

Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, outlines approaches to modulate the immune system in myeloid malignancies including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Whilst targeting T-cell immune checkpoint inhibitors (ICIs) such as PD-1 and PD-L1 has not been very successful, targeting other ICIs including CTLA-4, TIM-3, CD47/SIRPα, and manipulating natural killer (NK) cells has led to more promising results. This interview took place at the Tenth Annual Meeting of the Society of Hematologic Oncology (SOHO) held in Houston, TX.

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