Brian Walker, PhD of the UAMS Myeloma Institute, Little Rock, AR gives an overview of his talk on the molecular pathogenesis of myeloma. He talks about his research which has looked at the different stages of myeloma and how the genetics vary in the different disease time points. Furthermore, it has been determined that myeloma is not a single disease, but can be divided based on genetic abnormalities and help determine the patient’s prognosis. Recorded at the 2017 European Multiple Myeloma Academy (EMMA) in Vienna, Austria. This program was sponsored by Celgene through an unrestricted educational grant to Video Journal of Hematological Oncology.