Andrius Zucenka, MD, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania, gives an overview of frontline treatment strategies for unfit patients with acute myeloid leukemia (AML), highlighting the addition of venetoclax to standard hypomethylating agents or low-dose cytarabine. For fit patients, Dr Zucenka comments on standard induction with midostaurin, as well as the potential roles of CPX-351 and gemtuzumab in the future. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.