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EHA 2018 | Treatment challenges in myelofibrosis

Treating myelofibrosis is accompanied by several complications that must be considered, including thrombocytopenia and anemia. In this video, recorded at the 23rd Congress of the European Hematology Association (EHA) 2018, held in Stockholm, Sweden, Claire Harrison, MD, FRCP, FRCPath, from Guy’s and St Thomas’ Hospital, London, UK, speaks about how to address these challenges in myelofibrosis and other myeloproliferative neoplasms. She discusses how activin receptor antagonists like luspatercept can release the block on the terminal phases of erythropoiesis for anemia management, and how thrombocytopenia can be treated using combination therapies. Finally, she discusses how to identify disease progression in patients treated with JAK inhibitors, and how to combat this progression, again mentioning combination therapies.