Maria-Victoria Mateos, MD, PhD, University of Salamanca, Salamanca, Spain, discusses the ten-year follow-up for a Phase II trial in smoldering myeloma at high-risk of progression to myeloma, outlining the sustained time to progression and overall survival benefit with lenalidomide (len) and dexamethasone (dex) versus no treatment. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).