Naveen Pemmaraju, MD, University of Texas MD Anderson Cancer Center, Houston, TX, highlights key updates in hematological oncology (hem-onc) at the American Society of Clinical Oncology (ASCO) Annual Meeting, including novel JAK inhibitors such as pacritinib and momelotinib in patients with myeloproliferative neoplasms, as well as immunotherapy and CAR T-cell therapies being explored in lymphoma and multiple myeloma. This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.