Yi Lin, MD, PhD, of the Mayo Clinic, Rochester, MN, shares her views on the latest real world data on CAR T-cell therapy presented at the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA. This includes how axicabtagene ciloleucel transitions from clinical trials into real world practice, the emergence of CD30 as a target, and the surge in CAR T-cell research in China. In the multiple myeloma space, the anti-BCMA CAR T-cell product LCAR-B38M is under investigation (LEGEND-2; NCT03090659).