Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, comments on safety outcomes in the KarMMa-3 trial (NCT03651128) comparing CAR T-cell (CAR-T) therapy to standard triplet combinations for triple-class-exposed relapsed/refractory (R/R) multiple myeloma (MM). While initial severity of cytopenias and rates of infections are elevated with CAR-T therapy, this recovers after ~3 months, eliminating overall safety concerns associated with this type of therapy. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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