Smoldering multiple myeloma (SMM) is the ideal stage to treat the disease and prevent progression to multiple myeloma (MM). Here, Maria-Victoria Mateos, MD, PhD, of the University of Salamanca, Salamanca, Spain, discusses how SMM should be monitored in terms of biology, clinical aspects, imaging and MRD. This video was recorded at the European School of Haematology (ESH) International Conference on MM 2018, held in Mandelieu, France.