In this video, we hear Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, and Sigurdur Kristinsson, MD, PhD, University of Iceland, Reykjavík, Iceland, give their highlights from COMy 2022, including thoughts on a cure in multiple myeloma, imaging for patients and iStopMM. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.