Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, shares some insights into the safety and efficacy of belantamab mafodotin for the treatment of multiple myeloma. Dr Cerchione highlights the impressive results observed in many clinical trials evaluating the use of belantamab, including the DREAMM-2 (NCT03525678), DREAMM-7 (NCT04246047), and DREAMM-9 (NCT04091126) trials. Dr Cerchione also highlights the possibility of combining belantamab with other agents in the frontline setting, and the excitement surrounding the use of this agent in the future. This interview took place at the 8th World Congress on Controversies in Multiple Myeloma (COMy) 2022, held in Paris, France.