Maria-Victoria Mateos, MD, PhD, University Hospital of Salamanca, Salamanca, Spain, discusses the latest results from the GEM-CESAR trial (NCT02415413) of a curative treatment strategy for high-risk smoldering myeloma. This phase II trial consists of induction with carfilzomib, lenalidomide and dexamethasone (KRd), followed by HDT-ASCT, consolidation with KRd and maintenance with Rd. Dr Mateos mentions a planned amendment to this trial and highlights the importance of early detection and early intervention in smoldering myeloma. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.