Krish Patel, MD, Swedish Cancer Institute, Seattle, WA, outlines current and future treatment strategies for chronic lymphocytic leukemia (CLL), commenting on the move away from chemotherapy and towards more targeted agents in the frontline setting. In particular, Dr Patel talks on options for patients who have relapsed on both a BTK inhibitor and a BCL-2 inhibitor. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.