In this video, Paul Richardson, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the safety and efficacy of isatuximab for the treatment of relapsed/refractory (R/R) multiple myeloma based on data obtained from several trials, including the ICARIA-MM trial (NCT02990338), the IKEMA trial (NCT03275285), and the CANDOR trial (NCT03158688). Dr Richardson also comments on the importance of carefully interpreting data from cross-trial comparisons and further compares the mechanism of action of isatuximab versus daratumumab, further highlighting the importance of antibody therapies in myeloma. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.