Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD, of the University College London Hospitals, London, UK, explores the use of proteasome inhibitors in multiple myeloma treatment as well as new approaches investigated in the ENDURANCE study (NCT01863550), comparing RVD and kRD. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).