ASH 2023 | Thalassemia highlights at ASH 2023: novel therapies, trial updates & the value of precision medicine

In this discussion, Maria Domenica Cappellini, MD, University of Milan, Milan, Italy, and Kevin Kuo, MD, MSc, FRCPC, University Health Network, Toronto, Canada, share key highlights in thalassemia presented at ASH 2023. Dr Cappellini and Dr Kuo first discuss the promise of novel gene therapies in thalassemia, highlighting the recent approval of two of these agents in the sickle cell space. Following this, the experts discuss updates with the use of luspatercept in thalassemia, summarizing data from the BEYOND trial (NCT03342404), and comment on other disease-modifying agents being explored. To conclude, Dr Cappellini and Dr Kuo share insights into the challenges of treating patients with thalassemia, the limitations of gene therapy in certain patient populations, and the value of precision medicine. This discussion took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.