ASCO 2023 | Mechanisms of resistance to CAR-T in ALL: T-cell fitness, antigen loss and immunological rejection
Claire Roddie
• 3 Jun 2023
Claire Roddie, MD, PhD, University College London Cancer Institute, London, UK, gives an overview of mechanisms of resistance to CAR-T cell therapy in acute lymphoblastic leukemia (ALL), and further highlights strategies being explored to overcome these. Dr Roddie explains three of these mechanisms, including T-cell fitness, loss of target antigen, and immunological rejection. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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