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ASCO 2023 | Safety and efficacy of obe-cel in R/R adult B-ALL: results of the pivotal FELIX study

Claire Roddie, MD, PhD, University College London Cancer Institute, London, UK, comments on the results from the Phase Ib/II FELIX study (NCT04404660), which is evaluating the safety and efficacy of obecabtagene autoleucel (obe-cel), a fast-off rate CD19 CAR, in patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). Dr Roddie shares some insights into the design and rationale of this trial, as well as the demographics of the patient population. Preliminary results demonstrate that 76% of patients achieved a complete response, with 97% of these responses being measurable residual disease (MRD) negative. Obe-cel has also demonstrated a promising toxicity profile and appears to be well tolerated in this group of high-risk patients. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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