Ciltacabtagene autoleucel (cilta-cel), an investigational B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy. In this Video, Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, talks on CARTITUDE-1 (NCT03548207), a study which investigated the use of cilta-cel in relapsed/refractory (R/R) multiple myeloma and highlights cytokine release syndrome (CRS) in those treated. This interview took place during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, 2020.