Fredrik Schjesvold, MD, PhD, Oslo University Hospital, Oslo, Norway, shares his views on whether all patients with multiple myeloma should be treated with daratumumab in the first line at ESH MM 2021. Dr Schjesvold highlights variations in daratumumab efficacy in different patient subgroups and outlines the risks of complications. This interview took place during the 3rd European Society of Hematology How to Diagnose and Treat Multiple Myeloma (ESH MM) 2021 congress.