A major area of unmet clinical need is the management of patients that relapse post-transplant in acute myeloid leukemia (AML). Here, Charles Craddock, CBE, FRCP(UK), FRCPath, DPhil, of the University of Birmingham, Birmingham, UK, discusses the therapeutic options that can help address this unmet need. This interview was recorded at the American Society of Oncology (ASCO) 2019 Annual Meeting, held in Chicago, IL.