The European Research Initiative on Chronic Lymphocytic Leukemia (ERIC) supports large-scale collaborations across multiple centres to characterize relevant mutations in chronic lymphocytic leukemia (CLL). Here, Richard Rosenquist, MD, PhD, of the Karolinska University Hospital, Solna, Sweden, discusses these efforts and explores future steps, such as identifying the frequency, co-occurrence and prognostic value of genetic aberrations. This interview took place at the ERIC International Meeting 2018, held in Barcelona, Spain.