Farhad Ravandi, MD, University of Texas MD Anderson Cancer Center, Houston, TX, discusses the rationale and design of the COVALENT-101 study (NCT05153330) which evaluates the tolerability and efficacy of BMF-219, a novel oral irreversible menin inhibitor, in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma. This interview took place at the European Hematology Association (EHA) Congress 2022 held in Vienna, Austria.