Luciano Costa, MD, PhD, University of Alabama at Birmingham, Birmingham, AL, discusses the analysis of selinexor plus dexamethasone (Sd) vs. conventional care for triple class refractory, penta-exposed multiple myeloma in terms of overall survival (OS). This compared data from the STORM trial (NCT02336815) with real world data from the retrospective MAMMOTH study. While not an replacement for a prospective, randomized trial, this analysis suggested improved OS with Sd vs. conventional care in this group. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.