An unmet need in follicular lymphoma is an improved ability to predict those at greatest risk of early failure at diagnosis, in order to identify better treatments. Here Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, discusses recent research findings about the predictive nature of intrafollicular T-cells in newly diagnosed follicular lymphoma patients. This interview took place at the American Society of Hematology (ASH) 2019 Annual Meeting and Exposition in Orlando, FL.