Anthony Mato, MD, MSCE, Memorial Sloan Kettering Cancer Center, New York, NY, highlights data from the Phase I/II triple therapy study of umbralisib and ublituximab (‘U2’) combined with checkpoint inhibition in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL) and Richter’s transformation. This interview took place at the 18th International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Biennial Meeting, held in Edinburgh, UK.